Deletions in Klebsiella pneumoniae R plasmids induced by growth in the presence of acridine orange at high temperature.
نویسندگان
چکیده
The generation in vivo of plasmids deleted at specific sites in strains of Klebsiella pneumoniae containing R plasmids, by treatment with high concentrations of acridine orange (1.2 mg/ml) at 42 degrees C are reported. These deletions seem to be site specific because loss of specific restriction fragments after digestion with restriction enzymes was demonstrated.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 25 5 شماره
صفحات -
تاریخ انتشار 1984